Recent News

Apr
12
2018

PMN12.5 released

By admin

We are pleased to announce PMN12.5 release. In this release we added locus IDs to genes in all PMN databases. The locus IDs were extracted from public genome releases that were used in constructing the PMN metabolic pathway databases. Protein sequence IDs from the genome releases are associated with proteins. The locus IDs, along with protein sequence IDs, should greatly facilitate data query and usage. Additional data cleaning was done to several databases, most noticeably in AraCyc where we removed more than 140 redundant gene entries.

May
11
2017

PMN 12.0 released!

By admin

We are pleased to announce the PMN12 release. In this release we introduce 54 new species-specific metabolic pathway databases, which brings the total number of species-specific databases to 76.  The 76 species cover the green plant lineage widely, including green algae, a moss, a club moss, a basal flowering plant, and higher plants of monocots and eudicots. They include major crops from grains to vegetables and fruits. Several medicinal plants are also added to this release, such as Madagascar periwinkle (Catharanthus roseus), red sage (Salvia miltiorrhiza) and flax (Linum usitatissimum). The new release also expands the number of species in three plant families: 17 species in Poaceae, 13 in Brassicaceae and 6 in Fabaceae.

Examples of new species-specific metabolic pathway databases:

Bread wheat

Carrot

Spinach

Sweet orange

Sugar beet

Madagascar periwinkle

Please find complete list of databases here.

 

An important note about downloading complete PMN databases:

The following five databases were constructed from genome releases which are under prepublication data usage restrictions and thus can only be accessed by online searching and browsing at the PMN web site: AhalleriCyc (version 1.0) (Arabidopsis halleri), LperrieriCyc (1.0) (Leersia perrieri), ObrachyanthaCyc (1.0) (Oryza brachyantha), OpunctataCyc (1.0) (Oryza punctate), OrufipogonCyc (1.0) (Oryza rufipogon). Please see detailed data policy at the corresponding species page from Phytozome (https://phytozome.jgi.doe.gov/pz/portal.html) or EnsemblPlants (http://plants.ensembl.org/index.html).

CornCyc (version 8.0) was constructed from the maize B73 RefGen_V4 genome release, which is also under prepublication data usage restrictions. We communicated with the genome release provider and was allowed to provide the PMN users full access to the CornCyc database, online browsing and complete download. However we ask that you respect the data usage restrictions posted on http://plants.ensembl.org/Zea_mays/Info/Index. The preprint of the maize B73 RefGen_V4 genome paper can be found at http://biorxiv.org/content/early/2016/12/19/079004.

 

Jun
02
2016

PMN 11.0 released!

By admin

We are pleased to announce the PMN11 release. Highlights include the addition of curated information of rate-limiting steps in over 50 pathways. To see an example, follow this link,

http://pmn.plantcyc.org/PLANT/NEW-IMAGE?type=PATHWAY&object=PWY-695

To see a complete list of pathways with rate-limiting info, follow this link,

http://pmn.plantcyc.org/group?id=pmn-prod.dpb.carnegiescience.edu-1-3673...

Clicking on any pathway from the SmartTable, you will see a pathway diagram where the rate-limiting reaction is indicated with an icon of hourglass. Mouse over the icon to see the literature source of the curated rate-limiting data. We will continue curating and adding available rate-limiting data from the literature.

In this release we removed additional data of macro-molecule metabolism from the PMN databases, including enzymes, reactions and pathways that metabolize or modify proteins, DNAs, and RNAs.

The PMN databases are now updated to the Pathway Tools 19.5 data schema.

Jun
05
2015

PMN 10.0 released!

By admin

We are pleased to announce the PMN10 release. In this release, we introduce 5 new metabolic pathway databases for species including tomato, potato, two diploid progenitors of the bread wheat, Aegilops tauschii  (D-genome) and Triticum Urartu (A-genome), and the great duckweed (Spirodela polyrhiza). We substantially updated the 17 existing species-specific databases and the multi-species database PlantCyc. PMN now hosts 23 databases in total.

The computational predictions of enzyme functions in PMN 10 are based on an enhanced Ensemble Enzyme Prediction Pipeline (E2P2 v3.0), with increased precision and a 62% increase of enzyme function space. We also made the following major changes to the scope and rules used in PMNs databases:

  1. To reinforce the PMNs focus on small molecule metabolism, enzymes that metabolize macromolecules such as serine protein kinase are excluded from the pathway databases.
  2. In our enzyme to reaction association, EC number-based enzyme predictions are transferred to distinct MetaCyc reaction IDs. To reduce false-positive associations, when multiple MetaCyc reactions exist for the same EC number, only the MetaCyc reaction corresponding to the official EC reaction is used for annotation.
  3. When multiple splice variants of a gene locus exist in a genome, only the protein sequence that represents the longest coding sequence is included in the pathway database.
Nov
05
2014

PlantCyc 9.5 and PapayaCyc 3.5 release

By admin

We are pleased to announce PlantCyc 9.5, which fixes a bug in PlantCyc (version 9.0), which was released in September 5, 2014. This bug was caused by internal ID conflict affected only P. patens and C. papaya enzyme annotations in PlantCyc (9.0). Overall, the incorrect annotations accounted for about 2% of total enzyme annotations in PlantCyc (9.0). We have now fixed the problem in PlantCyc 9.5. Also released is an updated PapayaCyc 3.5 with new internal IDs.

PlantCyc 9.5 and PapayaCyc 3.5 will be available for download on our ftp site shortly (on Nov 7th). 

Sep
01
2014

PMN 9.0 provides enhanced predictions of enzymes, reactions and pathways!

By admin

We improved enzyme and reaction prediction using our new version Ensemble Enzyme Prediction Pipeline (E2P2 v2.1) and update all the 17 species-specific databases.

Jul
01
2013

PlantCyc 8.0 joins 17 species-specific databases at the PMN: Grasses galore and much more!

By admin

Grasses galore and much more! 

We continue to roll out our PMN 8 release that started in June: 

New additions:

Released in June 2013:
Seven new databases:

Seven updated databases:

Plus explore new software features for data display and analysis at the PMN website.

Jun
01
2013

PMN 8.0 provides 17 species: Grasses galore and much more!

By admin

Grasses galore and much more! 

Seven new databases:

Ten updated databases:

Plus explore new software features for data display and analysis at the PMN website.

Oct
01
2012

Get your data groove going with Groups!

By admin

Get the data you want in the format you need using the Groups functions at the PMN. 

* Got a list of up-regulated genes?

* Want to know all of the compounds present in the pathways they act in?

* Need to get their structures in SMILES or InChi format?

Then get going with PMN Groups! 

Simply register for free and then watch for opportunities to turn your search results into data-rich Groups.

Pages

The PMN is funded by the National Science Foundation (Grant #: 1546838, 1026003 and 0640769) and the Department of Energy (BER Grant #:  ER65472 ), governed by an Editorial Board composed of internationally renowned scientists, and executed at the Carnegie Institution for Science, Department of Plant Biology.